Review
doi: 10.1038/nrm3602.
Epub 2013 Jun 19.
A self-organization framework for symmetry breaking in the mammalian embryo
Affiliations
- PMID: 23778971
- DOI: 10.1038/nrm3602
Item in Clipboard
Review
A self-organization framework for symmetry breaking in the mammalian embryo
Nat Rev Mol Cell Biol.
2013 Jul.
Abstract
The mechanisms underlying the appearance of asymmetry between cells in the early embryo and consequently the specification of distinct cell lineages during mammalian development remain elusive. Recent experimental advances have revealed unexpected dynamics of and new complexity in this process. These findings can be integrated in a new unified framework that regards the early mammalian embryo as a self-organizing system.
Similar articles
-
Symmetry Breaking in the Mammalian Embryo.Annu Rev Cell Dev Biol. 2018 Oct 6;34:405-426. doi: 10.1146/annurev-cellbio-100617-062616. Epub 2018 Aug 10. Annu Rev Cell Dev Biol. 2018. PMID: 30095292 Review.
-
Tracing the origin of heterogeneity and symmetry breaking in the early mammalian embryo.Nat Commun. 2018 May 8;9(1):1819. doi: 10.1038/s41467-018-04155-2. Nat Commun. 2018. PMID: 29739935 Free PMC article. Review.
-
Principles of Self-Organization of the Mammalian Embryo.Cell. 2020 Dec 10;183(6):1467-1478. doi: 10.1016/j.cell.2020.11.003. Cell. 2020. PMID: 33306953 Free PMC article. Review.
-
The dynamics of morphogenesis in stem cell-based embryology: Novel insights for symmetry breaking.Dev Biol. 2021 Jun;474:82-90. doi: 10.1016/j.ydbio.2020.12.005. Epub 2020 Dec 15. Dev Biol. 2021. PMID: 33333067 Free PMC article. Review.
-
The Apical Domain Is Required and Sufficient for the First Lineage Segregation in the Mouse Embryo.Dev Cell. 2017 Feb 6;40(3):235-247.e7. doi: 10.1016/j.devcel.2017.01.006. Dev Cell. 2017. PMID: 28171747 Free PMC article.
Cited by
-
Engineering multicellular systems: using synthetic biology to control tissue self-organization.Curr Opin Biomed Eng. 2017 Dec;4:163-173. doi: 10.1016/j.cobme.2017.10.008. Curr Opin Biomed Eng. 2017. PMID: 29308442 Free PMC article. No abstract available.
-
The Principal Forces of Oocyte Polarity Are Evolutionary Conserved but May Not Affect the Contribution of the First Two Blastomeres to the Blastocyst Development in Mammals.PLoS One. 2016 Mar 31;11(3):e0148382. doi: 10.1371/journal.pone.0148382. eCollection 2016. PLoS One. 2016. PMID: 27030988 Free PMC article.
-
The role of self-organization in developmental evolution.Theory Biosci. 2014 Dec;133(3-4):145-63. doi: 10.1007/s12064-014-0200-4. Epub 2014 Apr 16. Theory Biosci. 2014. PMID: 24737046
-
Notch and hippo converge on Cdx2 to specify the trophectoderm lineage in the mouse blastocyst.Dev Cell. 2014 Aug 25;30(4):410-22. doi: 10.1016/j.devcel.2014.06.019. Epub 2014 Aug 7. Dev Cell. 2014. PMID: 25127056 Free PMC article.
-
Optogenetic control of Wnt signaling models cell-intrinsic embryogenic patterning using 2D human pluripotent stem cell culture.Development. 2023 Jul 15;150(14):dev201386. doi: 10.1242/dev.201386. Epub 2023 Jul 26. Development. 2023. PMID: 37401411 Free PMC article.
References
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
