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. 2013 Jun 11:4:104.
doi: 10.3389/fgene.2013.00104. eCollection 2013.

The UGT1A6_19_GG genotype is a breast cancer risk factor

Christina Justenhoven  1 , Ofure Obazee, Stefan Winter, Sylvia Rabstein, Anne Lotz, Volker Harth, Beate Pesch, Thomas Brüning, Christian Baisch, Jaana M Hartikainen, Arto Mannermaa, Veli-Matti Kosma, Vesa Kataja, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Mervi Grip, Peter A Fasching, Matthias Beckmann, Arif B Ekici, Alexander Hein, Per Hall, Jingmei Li, Jenny Chang-Claude, Dieter Flesch-Janys, Petra Seibold, Anja Rudolph, Ute Hamann, Yon-Dschun Ko, Hiltrud Brauch
Affiliations

The UGT1A6_19_GG genotype is a breast cancer risk factor

Christina Justenhoven et al. Front Genet. .

Abstract

Validation of an association between the UGT1A6_19_T>G (rs6759892) polymorphism and overall breast cancer risk. A pilot study included two population-based case-control studies from Germany (MARIE-GENICA). An independent validation study comprised four independent breast cancer case-control studies from Finland (KBCP, OBCS), Germany (BBCC), and Sweden (SASBAC). The pooled analysis included 7418 cases and 8720 controls from all six studies. Participants were of European descent. Genotyping was done by MALDI-TOF MS and statistical analysis was performed by logistic regression adjusted for age and study. The increased overall breast cancer risk for women with the UGT1A6_19_GG genotype which was observed in the pilot study was confirmed in the set of four independent study collections (OR 1.13, 95% CI 1.05-1.22; p = 0.001). The pooled study showed a similar effect (OR 1.09, 95% CI 1.04-1.14; p = 0.001). The risk effect on the basis of allele frequencies was highly significant, the pooled analysis showed an OR of 1.11 (95% CI 1.06-1.16; p = 5.8 × 10(-6)). We confirmed the association of UGT1A6_19_GG with increased overall breast cancer risk and conclude that our result from a well powered multi-stage study adds a novel candidate to the panel of validated breast cancer susceptibility loci.

Keywords: UGT1A6; breast cancer risk; metabolism; polymorphism; validation.

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