Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Jul;13(7):455-65.
doi: 10.1038/nrc3538. Epub 2013 Jun 20.

Decoding and unlocking the BCL-2 dependency of cancer cells

Philippe Juin  1 , Olivier Geneste, Fabien Gautier, Stéphane Depil, Mario Campone
Affiliations
Review

Decoding and unlocking the BCL-2 dependency of cancer cells

Philippe Juin et al. Nat Rev Cancer. 2013 Jul.

Abstract

Cancer cells are subject to many apoptotic stimuli that would kill them were it not for compensatory prosurvival alterations. BCL-2-like (BCL-2L) proteins contribute to such aberrant behaviour by engaging a network of interactions that is potent at promoting survival but that is also fragile: inhibition of a restricted number of interactions may suffice to trigger cancer cell death. Currently available and novel compounds that inhibit these interactions could be efficient therapeutic agents if this phenotype of BCL-2L dependence was better understood at a molecular, cellular and systems level and if it could be diagnosed by relevant biomarkers.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Mol Cell Biol. 2011 Feb;31(4):832-44 - PubMed
    1. Cell Mol Life Sci. 2009 Apr;66(8):1326-36 - PubMed
    1. Mol Cell. 2005 Feb 4;17(3):393-403 - PubMed
    1. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10853-8 - PubMed
    1. Cancer Cell. 2009 Jun 2;15(6):489-500 - PubMed

MeSH terms

Substances