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. 1990 Aug;47(2):181-6.

Microdissection of the fragile X region

R N MacKinnon  1 , M C Hirst, M V Bell, J E Watson, U Claussen, H J Ludecke, G Senger, B Horsthemke, K E Davies
Affiliations

Microdissection of the fragile X region

R N MacKinnon et al. Am J Hum Genet. 1990 Aug.

Abstract

We have microdissected and cloned the region around the fragile site at Xq27.3 on the human X chromosome. All of the clones tested map to the Xq27-Xq28 region, and detailed mapping on a panel of somatic cell hybrids indicates that the microdissected library contains sequences derived from both sides of the fragile X mutation. Some of these clones give signals in rodent DNA. This library demonstrates the power of microdissection for the identification of potential coding sequences near a disease locus and provides a promising resource for the identification of the fragile X mutation.

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References

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