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Case Reports
. 2012 Apr 30;2(2):202a04.
doi: 10.5826/dpc.0202a04. Print 2012 Apr.

Sinus histiocytosis (Rosai-Dorfman disease) presenting with solitary cutaneous nodule: a very rare clinical entity

Emilia Duarte-Williamson  1 , Fiona Antony, Radu Rotarescu
Affiliations
Case Reports

Sinus histiocytosis (Rosai-Dorfman disease) presenting with solitary cutaneous nodule: a very rare clinical entity

Emilia Duarte-Williamson et al. Dermatol Pract Concept. .

Abstract

Sinus histiocytosis is a rare inflammatory disease mainly affecting the cervical lymph nodes, presenting with skin lesions in 10% of cases. Our patient had a solitary nodule on the trunk without any other clinical signs. The histology reported a dermal neoplasm composed mainly of macrophages and lymphocytes. Macrophages were aggregated in clusters resembling lymph node sinuses. Lymphophagocytosis or emperipolesis (the presence of an intact cell within the cytoplasm of another cell) was noted and the diagnosis of sinus histiocytosis established.

Keywords: Rosai-Dorfman; histiocytosis; nodule; sinus histiocytosis.

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Figures

Figure 1
Figure 1
Purple, soft, shiny nodule with a violaceous peripheral rim in the interscapular area. [Copyright: ©2012 Duarte-Williamson et al.]
Figure 2
Figure 2
(A) Dermal tumor composed of an infiltrate of cells expanding and filling the papillary dermis and spreading into the superficial reticular dermis showing a diffuse dermal infiltrate. Haematoxylin and eosin stain, original magnification ×10. (B) The infiltrate included macrophages, large number of lymphoid cells, modest number of plasma cells and smaller number of other inflammatory cells. Macrophages were aggregated in clusters resembling lymph node sinuses. Lymphophagocytosis or emperipolesis (the presence of an intact cell within the cytoplasm of another cell) was noticed. Haematoxylin and eosin stain, original magnification ×40. [Copyright: ©2012 Duarte-Williamson et al.]
Figure 2
Figure 2
(A) Dermal tumor composed of an infiltrate of cells expanding and filling the papillary dermis and spreading into the superficial reticular dermis showing a diffuse dermal infiltrate. Haematoxylin and eosin stain, original magnification ×10. (B) The infiltrate included macrophages, large number of lymphoid cells, modest number of plasma cells and smaller number of other inflammatory cells. Macrophages were aggregated in clusters resembling lymph node sinuses. Lymphophagocytosis or emperipolesis (the presence of an intact cell within the cytoplasm of another cell) was noticed. Haematoxylin and eosin stain, original magnification ×40. [Copyright: ©2012 Duarte-Williamson et al.]
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References

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