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Review

Cy7-Polyethylene glycol-cinnamoyl-Phe- D-Leu-Phe- D-Leu-Phe-Lys-NH2

Kam Leung  1
In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004.
[updated ].
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Review

Cy7-Polyethylene glycol-cinnamoyl-Phe- D-Leu-Phe- D-Leu-Phe-Lys-NH2

Kam Leung.
Free Books & Documents

Excerpt

The formyl peptide receptor (FPR) family consists of three receptor subtypes (FPR1–FPR3) (1). These G-protein–coupled receptors are found on leukocytes. FPR1 is highly expressed on neutrophils under inflammatory conditions for their emigration to the sites of injury and infection (2). However, collateral damage may occur, which can cause pain, edema, fever, and swelling. The peptide antagonist cinnamoyl-Phe-d-Leu-Phe-d-Leu-Phe-Lys-NH2 (cFlFlFK) specifically binds FPR1 on neutrophils (3). The peptide was conjugated with Gd-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid to the ε-amino group of Lys to form Gd-DOTA-cFlFlFK for use with MRI imaging of neutrophils at the sites of inflammation (4). Xiao et al. (5, 6) conjugated polyethylene glycol (PEG) to the ε-amino group and Cy7 to the N-terminal amino group of Lys as Cy7-PEG-cFlFlFK for use with near-infrared fluorescence (NIR) imaging of inflammation.

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References

    1. Ye R.D., Boulay F., Wang J.M., Dahlgren C., Gerard C., Parmentier M., Serhan C.N., Murphy P.M. International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family. . Pharmacol Rev. 2009;61(2):119–61. - PMC - PubMed
    1. Loitto V.M., Rasmusson B., Magnusson K.E. Assessment of neutrophil N-formyl peptide receptors by using antibodies and fluorescent peptides. . J Leukoc Biol. 2001;69(5):762–71. - PubMed
    1. Gavins F.N. Are formyl peptide receptors novel targets for therapeutic intervention in ischaemia-reperfusion injury? . Trends Pharmacol Sci. 2010;31(6):266–76. - PMC - PubMed
    1. Stasiuk G.J., Smith H., Wylezinska-Arridge M., Tremoleda J.L., Trigg W., Luthra S.K., Morisson Iveson V., Gavins F.N., Long N.J. Gd3+ cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation. . Chem Commun (Camb) 2013;49(6):564–6. - PubMed
    1. Xiao L., Zhang Y., Liu Z., Yang M., Pu L., Pan D. Synthesis of the Cyanine 7 labeled neutrophil-specific agents for noninvasive near infrared fluorescence imaging. . Bioorg Med Chem Lett. 2010;20(12):3515–7. - PubMed

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