Measuring and reporting glycemic control in clinical trials: building a path to consensus
- PMID: 23786891
- PMCID: PMC3706919
- DOI: 10.1186/cc12599
Measuring and reporting glycemic control in clinical trials: building a path to consensus
Abstract
Clinical trials over time have used a variety of approaches for both measuring tight glycemic control and reporting results. The review by Finfer and colleagues in this issue of Critical Care is a step toward consensus within the research community to standardize the way blood glucose is measured and reported in clinical trials. The authors propose using specific measures of central tendency and dispersion for reporting glucose, advocate the use of blood gas analyzers and elimination of point-of-care glucose monitors in the intensive care unit, and comment on performance of continuous glucose monitors. As we await the release of updated rules from the International Standards Organization and process the new rules from the Clinical Laboratory and Standards Institute to regulate glucose monitoring, these recommendations should trigger many more conversations within the field as we strive for uniformity. However, we need to be cautious in prematurely proposing and adopting standards of care that fail to account for newer technology and data in this rapidly growing area of research.
Comment on
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Clinical review: Consensus recommendations on measurement of blood glucose and reporting glycemic control in critically ill adults.Crit Care. 2013 Jun 14;17(3):229. doi: 10.1186/cc12537. Crit Care. 2013. PMID: 23767816 Free PMC article. Review.
References
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- Finfer S, Wernerman J, Preiser JC, Cass T, Desaive T, Hovorka R, Joseph JI, Kosiborod M, Krinsley J, Mackenzie I, Mesotten D, Schultz MJ, Scott MG, Slingerland R, Van den Berghe G, Van Herpe T. Clinical review: Consensus recommendations on 'Measurement of blood glucose and reporting glycemic control in critically ill adults'. Crit Care. 2013;17:229. doi: 10.1186/cc12537. - DOI - PMC - PubMed
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- Gijzen K, Moolenaar DL, Weusten JJ, Pluim HJ, Demir AY. Is there a suitable point-of-care glucose meter for tight glycemic control? Evaluation of one home-use and four hospital-use meters in an intensive care unit. Clin Chem Lab Med. 2012;50:1985–1992. - PubMed
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- ISO 15197:2003. In vitro diagnostic test systems--requirements for blood-glucose monitoring systems for self-testing in managing diabetes mellitus. 2009.
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- ISO/FDIS 15197. In vitro diagnostic test systems--requirements for blood-glucose monitoring systems for self-testing in managing diabetes mellitus. Under development, stage 50.20.
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