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. 2013 Jun 20;4(6):e678.
doi: 10.1038/cddis.2013.194.

Enriched environment and physical activity reverse astrogliodegeneration in the hippocampus of AD transgenic mice

J J Rodríguez, S Terzieva, M Olabarria, R G Lanza, A Verkhratsky

Enriched environment and physical activity reverse astrogliodegeneration in the hippocampus of AD transgenic mice

J J Rodríguez et al. Cell Death Dis. .
No abstract available

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Figures

Figure 1
Figure 1
GFAP-immunorectivity of astrocytes in the DG of non-Tg and 3xTg-AD animals housed in different conditions. (a) High magnification of representative confocal micrographs showing the astrocytic morphology in mice housed in standard conditions (STD;), RUN, and ENR. Scale bars, 10 μm. Note the morphological changes of the astrocytes from both genotypes induced by the different living conditions. (b) Histograms showing difference of surface area and volume of GFAP-positive astrocytes in the DG of non-Tg and 3xTg-AD mice housed under different housing conditions. (c) Histograms showing differences in surface area and volume of GFAP-IR astrocytic cell bodies and processes detected between non-Tg and 3xTg-AD mice housed under different housing conditions. Bars represent means±S.E.M., #P<0.05, ##P<0.01 compared with non-Tg animals in same housing environment; *P<0.05, **P<0.01 compared with non-Tg mice housed under STD; ⧫⧫P<0.01 and ⧫⧫⧫P<0.001 compared with3xTg-AD mice housed under STD
See this image and copyright information in PMC

References

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