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. 2013 Jun;54(6):404-8.
doi: 10.4111/kju.2013.54.6.404. Epub 2013 Jun 12.

Is the Expression of Androgen Receptor Protein Associated With the Length of AC Repeats in the Type III 5-α Reductase Gene in Prostate Cancer Patients?

Jong Mok Park  1 , Ki Hak Song, Jae Sung Lim, Jin Woo Kim, Chong Koo Sul
Affiliations

Is the Expression of Androgen Receptor Protein Associated With the Length of AC Repeats in the Type III 5-α Reductase Gene in Prostate Cancer Patients?

Jong Mok Park et al. Korean J Urol. 2013 Jun.

Abstract

Purpose: Type III 5-α reductase (SRD5A3; steroid 5-α reductase 3) may be associated with the progression of prostate cancer (PCa). The aim of our study was to determine whether the length of AC repeats in the SRD5A3 gene is associated with the risk of PCa and the expression of androgen receptor (AR) protein in Korean men.

Materials and methods: We compared the length of AC repeats in the short tandem repeat (STR) region of the SRD5A3 gene in 68 PCa patients and 81 control subjects by genotyping. A total of 55 patients in the PCa group underwent radical prostatectomy. We evaluated the expression of AR protein by using Western blotting and tested the association between the type of AC repeats in the SRD5A3 gene and AR protein expression and clinical and pathologic parameters.

Results: The short type of STR had less than 21 copies of AC repeats in the SRD5A3 gene. The SS type (short and short type) of STR of the SRD5A3 gene was 2.2 times as likely to occur in PCa patients as in controls (odds ratio, 2.21; 95% confidence interval, 1.14 to 4.31; p=0.019). However, AC repeats of the SRD5A3 gene were not associated with AR protein expression or clinical or pathologic parameters in PCa samples.

Conclusions: These results suggest that the short AC repeats of SRD5A3 polymorphism are associated with an increased risk of PCa. SRD5A3 polymorphism may contribute to a genetic predisposition for PCa.

Keywords: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Androgen receptors; Genetic polymorphism; Prostatic neoplasms.

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Conflict of interest statement

The authors have nothing to disclose.

Figures

FIG. 1
FIG. 1
Scheme of calculation for numbers of AC copies in SRD5A3 gene. For examples, if the value analyzed by GeneMapper program was 189.03, short tandem repeat was the 20 repeats as follow an equation; [(189.03).(91+58)]/2=20.015 (20 repeats).
FIG. 2
FIG. 2
The frequencies of SRD5A3 short tandem repeat between control and patients with prostate cancer. 42.6% of patients with prostate cancer (PCa) had the 20,20 genotype compared to 28.4% of control (χ2=2.97, df=1, p=0.084).
See this image and copyright information in PMC

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