Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Sep;37(9):1116-9.
doi: 10.1016/j.leukres.2013.05.016. Epub 2013 Jun 20.

Follicular lymphoma with leukemic phase at diagnosis: a series of seven cases and review of the literature

Brady E Beltran  1 , Pilar Quiñones, Domingo Morales, Jose C Alva, Roberto N Miranda, Gary Lu, Bijal D Shah, Eduardo M Sotomayor, Jorge J Castillo
Affiliations
Review

Follicular lymphoma with leukemic phase at diagnosis: a series of seven cases and review of the literature

Brady E Beltran et al. Leuk Res. 2013 Sep.

Abstract

Follicular lymphoma (FL) is a prevalent type of non-Hodgkin lymphoma in the United States and Europe. Although, FL typically presents with nodal involvement, extranodal sites are less common, and leukemic phase at diagnosis is rare. There is mounting evidence that leukemic presentation portends a worse prognosis in patients with FL. We describe 7 patients with a pathological diagnosis of FL who presented with a leukemic phase. We compared our cases with 24 additional cases reported in the literature. Based on our results, patients who present with leukemic FL tend to have higher risk disease. Leukemic FL also seems to be associated with a worse prognosis; however, larger studies are needed to confirm our findings. A discrepancy with previously reported cases of FL in leukemic phase raises the possibility of differences attributable to geographic regions.

Keywords: Extranodal; Follicular lymphoma; Leukemic phase; Lymphocytosis.

PubMed Disclaimer

References

    1. Morton LM, Wang SS, Devesa SS, et al. Lymphoma incidence patterns by WHO subtype in the United States, 1992–2001. Blood. 2006;107(1):265–276. - PMC - PubMed
    1. Anderson JR, Armitage JO, Weisenburger DD. Epidemiology of the non-Hodgkin's lymphomas: distributions of the major subtypes differ by geographic locations. Non-Hodgkin's Lymphoma Classification Project. Ann Oncol. 1998;9(7):717–720. - PubMed
    1. Laurini JA, Perry AM, Boilesen E, et al. Classification of non-Hodgkin lymphoma in Central and South America: a review of 1028 cases. Blood. 2012;120(24):4795–4801. - PubMed
    1. Medeiros LJ, Jaffe ES. Pathology of non-Hodgkin’s lymphomas and Hodgkin’s disease. In: Wiernik PH, et al., editors. Neoplastic diseases of the blood. New York: Churchil Livingstone; 1996. pp. 753–805.
    1. Chubachi A, Miura I, Hashimoto K, et al. High incidence of leukemic phase in follicular lymphoma in Akita, Japan: clinicopathologic, immunological and cytogenetic studies. Eur J Haematol. 1993;50(2):103–109. - PubMed