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Comment
. 2013 Jun 20;20(6):745-6.
doi: 10.1016/j.chembiol.2013.06.001.

Ins and outs of kinase DFG motifs

Daniel K Treiber  1 , Neil P Shah
Affiliations
Comment

Ins and outs of kinase DFG motifs

Daniel K Treiber et al. Chem Biol. .

Abstract

In this issue of Chemistry & Biology, Hari and colleagues show that two positions in kinase active sites, including the well-known "gatekeeper" residue, regulate "in" versus "out" conformations of the conserved "DFG" motif. These findings suggest yet another role for the gatekeeper residue.

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