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Multicenter Study
. 2013 Sep-Oct;7(5):353-62.
doi: 10.1016/j.jash.2013.05.003. Epub 2013 Jun 20.

A multicenter study of neurocognition in children with hypertension: methods, challenges, and solutions

Marc B Lande  1 , Heather R Adams, Juan C Kupferman, Stephen R Hooper, Peter G Szilagyi, Donald L Batisky
Affiliations
Multicenter Study

A multicenter study of neurocognition in children with hypertension: methods, challenges, and solutions

Marc B Lande et al. J Am Soc Hypertens. 2013 Sep-Oct.

Abstract

Hypertensive adults demonstrate decreased performance on neurocognitive testing compared with that of normotensive controls. There is now emerging, preliminary evidence that children with hypertension also manifest neurocognitive differences when compared with normotensive controls, findings postulated to potentially represent early signs of hypertensive target organ damage to the brain. However, reports in children to date have been limited to database and single-center studies. We have established an ongoing, prospective, multicenter study of neurocognition in children with primary hypertension. This article outlines the study methods, with particular attention to the unique challenges in this area of clinical research. We highlight aspects of the study design that are specifically designed as solutions to these challenges.

Keywords: Executive function; blood pressure; cognition; pediatric.

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Conflict of interest statement

None of the authors have any financial or other relations that could lead to a conflict of interest.

Figures

Figure 1
Figure 1. Study design
See this image and copyright information in PMC

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