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Comment
. 2013 Jul 31;32(15):2096-8.
doi: 10.1038/emboj.2013.151. Epub 2013 Jun 21.

Enhancer-derived RNAs: 'spicing up' transcription programs

Aisling M Redmond  1 , Jason S Carroll
Affiliations
Comment

Enhancer-derived RNAs: 'spicing up' transcription programs

Aisling M Redmond et al. EMBO J. .

Abstract

Nature 498, 511–515 doi:; DOI: 10.1038/nature12209; published online May 02 2013

Nature 498, 516–520 doi:; DOI: 10.1038/nature12210; published online May 02 2013

Recent reports established transcription of enhancer-derived RNAs (eRNAs), while the evidence for their functional significance remained mostly speculative. Two recent reports published in Nature (Lam et al, 2013; Li et al, 2013) offer the first functional evidence for eRNA transcripts. These analyses further reveal an unexpected level of specificity in the regulation of adjacent mRNAs by eRNAs.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
(A) Activation of transcription by eRNAs in the MCF-7 breast cancer setting is mediated by binding of ERα to enhancer regions, producing sequence-specific eRNAs that mediate looping from the enhancer region to the distal transcription start site by stabilizing Cohesin. (B) In macrophages, eRNAs produced from an enhancer site play a role in transcription of an adjacent gene. Binding of Rev-Erb proteins that bring in HDACs repress the production of these eRNAs and thus lead to the inactivation of the adjacent gene.
See this image and copyright information in PMC

Comment on

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