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Comment
. 2013 Aug;9(8):470-1.
doi: 10.1038/nchembio.1291. Epub 2013 Jun 23.

Protein engineering: Chemistry gets the assist

Bettina M Nestl, Bernhard Hauer
Comment

Protein engineering: Chemistry gets the assist

Bettina M Nestl et al. Nat Chem Biol. 2013 Aug.

Abstract

Integration of chemistry-based approaches into enzyme engineering provides a versatile strategy for biocatalyst development with the potential for improved performance and new catalytic activities. Application of this strategy led to the development of a whole-cell catalyst capable of converting olefins into cyclopropanes, synthetic intermediates used in the synthesis of more functionalized cycloalkanes and acyclic compounds.

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References

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    1. Protein Eng Des Sel. 2012 Apr;25(4):171-8 - PubMed
    1. Nat Chem Biol. 2013 Aug;9(8):485-7 - PubMed
    1. Chem Soc Rev. 2012 Jul 7;41(13):4631-42 - PubMed
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