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. 2013 Jul 23;81(4):346-52.
doi: 10.1212/WNL.0b013e31829c5c86. Epub 2013 Jun 21.

Evolution of mild cognitive impairment in Parkinson disease

M Broeders  1 , R M A de Bie, D C Velseboer, J D Speelman, D Muslimovic, B Schmand
Affiliations

Evolution of mild cognitive impairment in Parkinson disease

M Broeders et al. Neurology. .

Abstract

Objective: We examined the development of Parkinson disease (PD)-mild cognitive impairment (MCI) in patients with newly diagnosed PD over 5 years using recently proposed consensus criteria, and we assessed the reliability of the criteria.

Methods: Patients with PD (n = 123) underwent extensive neuropsychological testing at baseline and after 3 (n = 93) and 5 years (n = 59). Two neuropsychologists independently applied the PD-MCI criteria to examine the interrater and intrarater reliability.

Results: At baseline, 35% of patients had PD-MCI. Three years later, 53% of the patients had PD-MCI. At 5-year follow-up, 20 patients who had PD-MCI at an earlier assessment had converted to PD dementia and 50% of the remaining patients without dementia had MCI. The interrater reliability (kappa) was 0.91. The intrarater reliabilities were 0.85 and 0.96.

Conclusion: Approximately one-third of patients with newly diagnosed PD fulfill the consensus criteria for PD-MCI; after 5 years, this proportion is approximately 50% of patients without dementia. The criteria have good interrater and intrarater reliability.

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