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Review
. 2013 Jul 1;191(1):17-23.
doi: 10.4049/jimmunol.1300654.

Reciprocal relationship between myeloid-derived suppressor cells and T cells

Srinivas Nagaraj  1 , Je-In Youn, Dmitry I Gabrilovich
Affiliations
Review

Reciprocal relationship between myeloid-derived suppressor cells and T cells

Srinivas Nagaraj et al. J Immunol. .

Abstract

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid cells that play a major role in the regulation of immune responses in many pathological conditions. These cells have a common myeloid origin, relatively immature state, common genetic and biochemical profiles, and, most importantly, the ability to inhibit immune responses. Although initial studies of MDSCs were almost exclusively performed in tumor-bearing mice or cancer patients, in recent years, it became clear that MDSCs play a critical role in the regulation of different types of inflammation that are not directly associated with cancer. In this review we discuss the nature of the complex relationship between MDSCs and the different populations of CD4(+) T cells.

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Figures

Figure
Figure. Complex interaction between MDSC and different populations of T cells
See description in the text.
See this image and copyright information in PMC

References

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