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Comment
. 2013 Jun 11:2:e00914.
doi: 10.7554/eLife.00914.

Rad51, friend or foe?

Sue Mei Tan-Wong  1 , Nick J Proudfoot
Affiliations
Comment

Rad51, friend or foe?

Sue Mei Tan-Wong et al. Elife. .

Abstract

A protein long recognized for its role in DNA repair has now paradoxically been implicated in DNA damage.

Keywords: DNA repair; Genome Instability; R loops; RNA-DNA hybrids; Rad51; S. cerevisiae.

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Conflict of interest statement

Competing interests:The authors declare that no competing interests exist.

Figures

Figure 1.
Figure 1.. Rad51 can contribute to DNA repair or DNA assault.
Left: DNA repair through homologous recombination, where one strand is used as a template to repair the other. DNA damage (red bolt) leads to double-strand breaks. At the break point, one strand of the DNA is slightly longer than the other and Rad52 (not shown) promotes the loading of Rad51 (orange) onto these single-strand overhangs. This initiates the process of DNA repair via homologous recombination. Rad51 is removed from the single-strand overhangs by the negative regulator Srs2 (not shown) before the final stages of DNA repair. Right: Rad51 can promote the formation of DNA-RNA hybrids (R-loops), which can damage DNA. R-loops form when Rad51 binds repeatedly to RNA (red lines). Srs2 (not shown) inhibits R-loop formation by removing Rad51.
See this image and copyright information in PMC

Comment on

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