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Review
. 2013 Aug;14(8):523-34.
doi: 10.1038/nrg3495. Epub 2013 Jun 25.

PIWI-interacting RNAs: from generation to transgenerational epigenetics

Maartje J Luteijn  1 , René F Ketting
Affiliations
Review

PIWI-interacting RNAs: from generation to transgenerational epigenetics

Maartje J Luteijn et al. Nat Rev Genet. 2013 Aug.

Abstract

Small-RNA-guided gene regulation is a recurring theme in biology. Animal germ cells are characterized by an intriguing small-RNA-mediated gene-silencing mechanism known as the PIWI pathway. For a long time, both the biogenesis of PIWI-interacting RNAs (piRNAs) as well as their mode of gene silencing has remained elusive. A recent body of work is shedding more light on both aspects and implicates PIWI in the establishment of transgenerational epigenetic states. In fact, the epigenetic states imposed by PIWI on targets may actually drive piRNA production itself. These findings start to couple small RNA biogenesis with small-RNA-mediated epigenetics.

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References

    1. Dev Cell. 2002 Jun;2(6):819-30 - PubMed
    1. Curr Opin Genet Dev. 2010 Apr;20(2):134-41 - PubMed
    1. Cell. 2012 Dec 21;151(7):1488-500 - PubMed
    1. Science. 2007 May 4;316(5825):744-7 - PubMed
    1. Cell. 2012 Jul 6;150(1):65-77 - PubMed

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