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Case Reports
. 2013 Jan;17(1):139-42.
doi: 10.4103/0973-029X.110722.

Disseminated histoplasmosis with oral and cutaneous manifestations

S Vidyanath  1 , Pm Shameena, S Sudha, Resmi G Nair
Affiliations
Case Reports

Disseminated histoplasmosis with oral and cutaneous manifestations

S Vidyanath et al. J Oral Maxillofac Pathol. 2013 Jan.

Abstract

Histoplasmosis is a systemic mycotic infection caused by the dimorphic fungus, Histoplasma capsulatum. Systemic histoplasmosis has emerged as an important opportunistic infection in human immunodeficiency virus (HIV) patients and those in endemic areas. Reported cases of histoplasmosis have been low in India with less than 50 cases being reported. We are reporting a case of disseminated histoplasmosis with oral and cutaneous involvement in an HIV seronegative patient.

Keywords: Disseminated; histoplasmosis; human immunodeficiency virus.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
(a) Intraoral examination shows ulcerated and necrotic lesions, (b) Intraoral examination shows coating of the tongue, (c) Extraoral examination shows multiple nodular lesions on the chin, right side of the face and upper lip with an erythematous surface, (d) Multiple plaques like areas on the ventral surface of the forearm, (e) Multiple plaques like areas on the dorsal aspect of thigh
Figure 2
Figure 2
(a) Histopathology shows presence of epithelioid cell granulomas in the connective tissue with numerous histiocytes and multinucleated giant cells. The cytoplasm of the histiocytes shows the presence of small round to oval basophilic bodies surrounded by a clear halo (H and E, ×40), (b) Small round to oval basophilic bodies surrounded by a clear halo is seen in the cytoplasm of histiocytes (H and E, ×100), (c) High power view of the same field (H and E, ×400)
Figure 3
Figure 3
(a) Round to oval basophilic bodies surrounded by a clear halo in the histiocytes (Gomori's methanimine silver, ×100), (b) High power view of the same field (GMS, ×400)
See this image and copyright information in PMC

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