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. 2012 Aug;17(8):760-3.

A comparison between cetirizine and ondansetron in preventing postoperative nausea and vomiting in adults

Seyed M Lahsaei  1 , Afshin Amini, Seyed M N Tabatabei, Golnoush Mehrabani
Affiliations

A comparison between cetirizine and ondansetron in preventing postoperative nausea and vomiting in adults

Seyed M Lahsaei et al. J Res Med Sci. 2012 Aug.

Abstract

Background: Postoperative nausea and vomiting are some of the important and common side effects of anesthesia after surgery occurring in almost 20-30% of patients and is the second factor of a patient's complaint and inconvenience after pain. This study compares the effect of oral cetirizine and ondansetron in the prevention of postoperative nausea and vomiting in adults.

Materials and methods: In a blind and prospective study in fall 2010, 300 patients aged 18-65 years who were among ASA I-II in Chamran Orthopedic Hospital were randomly divided into three equal groups receiving cetirizine, ondansetron, and placebo, respectively. General anesthesia was identical. After operation (after 1-2 h in the recovery room, after 2-12 and 12-24 h in the ward), the presence or absence and any nausea or vomiting was recorded.

Results: The postoperative nausea and vomiting (PONV) rate after 1-2 h in the recovery room, after 2-12 and 12-24 h in the ward in placebo, and both groups of cetirizine and ondansetron were 50%, 21%, and 11%, respectively while the difference was significant (P value < 0.05). Regarding the number of vomiting, the least was related to ondansetron (especially in the first 2-12 h) but the difference was not significant (P > 0.05).

Conclusion: The PONV rate in cetirizine and ondansetron groups was less than the placebo group.

Keywords: Anesthesia; cetirizine; nausea; ondansetron; postoperative; vomiting.

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Conflict of interest statement

Conflict of Interest: None declared.

References

    1. Apfel CC. Postoperative nausea and vomiting. In: Miller RD, editor. Miller's Anesthesia. Churchill Livingstone; 2010. pp. 2729–55.
    1. Gupta D, Bhatnagar S, Mishra S, Singh MS. Pre-emptive anti-emesis with oral setrons in patients undergoing radical mastectomy. Anesthesiol. 2000;107:A2092.
    1. Lee Y, Wang JJ, Yang YL, Chen A, Lai H. Midazolam vs ondansetron for preventive postoperative nausea and vomiting; a randomized controlled trial. Anaesthesia. 2007;62:18–22. - PubMed
    1. Gin T, Kan PK, Tang YK, Benny CC, Chan MT. Cetirizine for preventing postoperative nausea and vomiting at laparoscopy. Anaesthesiol. 2007;107:A1051.
    1. White PF, Tang J, Hamza MA, Ogunnaike B, Wender RH. The use of oral granisetron vs IV ondansetron for antiemetic prophylaxis in patients undergoing laparoscopic surgery: The effect on emetic symptoms and quality of recovery. Anesth Analg. 2006;102:1387–93. - PubMed

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