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Case Reports
. 2013 Jun;22(2):205-8.

De-novo onset of eosinophilic esophagitis after large volume allergen exposures

W Asher Wolf  1 , Maya R Jerath, Evan S Dellon
Affiliations
Case Reports

De-novo onset of eosinophilic esophagitis after large volume allergen exposures

W Asher Wolf et al. J Gastrointestin Liver Dis. 2013 Jun.

Abstract

Eosinophilic esophagitis (EoE) is a chronic immune-mediated condition believed to have an allergic component, but the timing of the initial allergen triggers that cause the disease is poorly understood. While the clinical presentation of EoE is often of longstanding symptoms, in animal models, acute exposure to an allergen challenge successfully produces EoE. In this report, we present three cases of individuals who developed esophageal eosinophilia and EoE shortly after a clearly identified exposure to aeroallergens. These cases highlight the allergic etiology of EoE, and provide a link from humans to the previously described experimental mechanisms.

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Conflict of interest statement

Disclosures: There are no potential conflicts of interest for any of the authors pertaining to this study.

Figures

Figure 1
Figure 1
Endoscopic views of the esophagus in case 1 prior to (A) and after (B) PPI therapy. Before PPI, there are prominent fixed esophageal rings and decreased vascularity. After PPI, the rings are nearly resolved and vascularity is normal.
Figure 1
Figure 1
Endoscopic views of the esophagus in case 1 prior to (A) and after (B) PPI therapy. Before PPI, there are prominent fixed esophageal rings and decreased vascularity. After PPI, the rings are nearly resolved and vascularity is normal.
Figure 2
Figure 2
Endoscopic view of case 2 with esophageal rings, linear furrows, and decreased vascularity.
Figure 3
Figure 3
Endoscopic view of case 3 with esophageal rings, linear furrows, and decreased vascularity.
See this image and copyright information in PMC

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