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. 2013 Jun 25;14(7):13063-77.
doi: 10.3390/ijms140713063.

New Labdane-type diterpenoids and anti-inflammatory constituents from Hedychium coronarium

Jih-Jung Chen  1 , Chia-Wei Ting, Yi-Chin Wu, Tsong-Long Hwang, Ming-Jen Cheng, Ping-Jyun Sung, Tai-Chi Wang, Jinn-Fen Chen
Affiliations

New Labdane-type diterpenoids and anti-inflammatory constituents from Hedychium coronarium

Jih-Jung Chen et al. Int J Mol Sci. .

Abstract

Four new labdane-type diterpenoids: hedychicoronarin (1), peroxycoronarin D (2), 7β-hydroxycalcaratarin A (3), and (E)-7β-hydroxy-6-oxo-labda-8(17),12-diene-15,16-dial (4), have been isolated from the rhizomes of Hedychium coronarium, together with 13 known compounds (5-17). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 3, 5, 6, and 10 exhibited inhibition (IC50 values ≤4.52 μg/mL) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 3-6, 10, and 11 inhibited fMLP/CB-induced elastase release with IC50 values ≤6.17 μg/mL.

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Figures

Figure 1
Figure 1
The chemical structures of new compounds 1–4 isolated from H. coronarium.
Figure 2
Figure 2
The chemical structures of known compounds 5–17 isolated from H. coronarium.
Figure 3
Figure 3
Key NOESY (3a) and HMBC (3b) correlations of 1.
Figure 4
Figure 4
Key NOESY (4a) and HMBC (4b) correlations of 2.
Figure 5
Figure 5
Key NOESY (5a) and HMBC (5b) correlations of 3.
Figure 6
Figure 6
Key NOESY (6a) and HMBC (6b) correlations of 4.
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