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. 2013 Jun 22:10:32.
doi: 10.1186/1742-4755-10-32.

There is no relationship between Paraoxonase serum level activity in women with endometriosis and the stage of the disease: an observational study

Felipe Barca Bragatto  1 , Caio Parente Barbosa, Denise Maria Christofolini, Carla Peluso, Aline Amaro dos Santos, Fernanda Abani Mafra, Viviane Cavalcanti, Sonia Hix, Bianca Bianco
Affiliations

There is no relationship between Paraoxonase serum level activity in women with endometriosis and the stage of the disease: an observational study

Felipe Barca Bragatto et al. Reprod Health. .

Abstract

Background: Endometriosis is a chronic condition whose pathophysiology is unknown, but there is evidence suggesting a link with oxidative stress. Paraoxonase is a serum enzyme which circulates associated with high-density lipoprotein (HDL). It acts protecting HDL and LDL of lipid peroxidation. We aimed to compare the serum levels of PON-1 activity in women with endometriosis in different stages of the disease (minimal/mild and moderate/severe).

Methods: 80 infertile women with endometriosis diagnosed by laparoscopy/laparotomy with histologic confirmation of the disease were divided according to the American Society for Reproductive Medicine classification in minimal/mild (n = 33) and moderate/severe (n = 47) cases. Paraoxonase activity and arilesterase activity were measured by spectrophotometry. Body mass index and fasting glucose levels were also determined.

Results: The paraoxonase activity were 191.29 ± 22.41 U/l in women with minimal/mild endometriosis and 224.85 ± 21.50 U/l in women with moderate/severe disease (P = 0.274). Considering arilesterase level, the results showed 89.82 ± 4.61 U/l in women with minimal/mild endometriosis and 90.78 ± 3.43 U/l in moderate/severe disease (P = 0.888).

Conclusions: Evidence of lower paraoxonase activity in women with endometriosis was not found in this study. Besides, no difference was found considering minimal/mild or moderate/severe endometriosis.

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References

    1. Barbosa CP, Souza AM, Bianco B, Christofolini D, Mafra FA, Lima GR. Frequency of endometriotic lesions in peritoneum samples from asymptomatic fertile women and correlation with CA125 values. Sao Paulo Med J. 2009;127:342–345. doi: 10.1590/S1516-31802009000600004. - DOI - PMC - PubMed
    1. Barbosa CP, Souza AM, Bianco B, Christofolini D. The effects of hormones on endometriosis development. Minerva Ginecol. 2011;63:375–386. - PubMed
    1. Barbosa CP, de Souza AM, Bianco B, Christofolini D, Mafra FA, Lima GR. OC-125 Immunostaining in endometriotic lesion samples. Arch Gynecol Obstet. 2010;281:43–47. doi: 10.1007/s00404-009-1055-7. - DOI - PubMed
    1. De Andrade AZ, Rodrigues JK, Dib LA, Romão GS, Ferriani RA, Junior AAJ, Navarro PAAS. Serum markers of oxidative stress in infertile women with endometriosis. Rev Bras Ginecol Obstet. 2010;32:279–285. - PubMed
    1. Cabrera JM, Zamudio LJ, Latorre EG, Orozco OC, Guerrero CH. Quantitative and qualitative peritoneal imune profiles. T-cell apoptosis and oxidative stress-associated characteristics in women with minimal and mild endometriosis. BJOG. 2011;118:6–16. - PubMed

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