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Comparative Study
. 2013 Oct;43(10):1151-4.
doi: 10.1111/imj.12226.

Imipenem versus piperacillin/tazobactam for empiric treatment of neutropenic fever in adults

A Roohullah  1 , A Moniwa, C Wood, M Humble, M Balm, J Carter, R Weinkove
Affiliations
Comparative Study

Imipenem versus piperacillin/tazobactam for empiric treatment of neutropenic fever in adults

A Roohullah et al. Intern Med J. 2013 Oct.

Abstract

Australian guidelines for neutropenic fever recommend piperacillin/tazobactam (PIP-TAZ) or cefepime for first-line empiric treatment of neutropenic fever. We compared outcomes among haematology patients before and after changing our first-line neutropenic fever treatment from imipenem to PIP-TAZ. Forty-five patients received imipenem and 60 PIP-TAZ. Despite a higher rate of antibiotic modification in the PIP-TAZ cohort, treatment success and time to defervescence were similar, with a trend towards fewer Clostridium difficile infections in the PIP-TAZ cohort.

Keywords: imipenem; neutropenia; piperacillin; sepsis; tazobactam.

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