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. 1990 Jun;43(6):601-6.
doi: 10.7164/antibiotics.43.601.

A54145, a new lipopeptide antibiotic complex: microbial and chemical modification

D S Fukuda  1 , M Debono, R M Molloy, J S Mynderse
Affiliations
Free article

A54145, a new lipopeptide antibiotic complex: microbial and chemical modification

D S Fukuda et al. J Antibiot (Tokyo). 1990 Jun.
Free article

Abstract

A54145 is a complex of acidic lipopeptide antibiotics produced by Streptomyces fradiae NRRL 18158, NRRL 18159, and NRRL 18160. Each antibiotic factor consists of a peptide core bearing an N-terminal acyl substituent. N-Lys-tert-BOC-protected A54145 complex was deacylated by Actinoplanes utahensis; three protected core peptides were isolated. A54145 antibiotic analogs were synthesized by acylation of the tryptophan N-terminus with 2,4,5-trichlorophenyl active esters, followed by deblocking with trifluoroacetic acid.

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