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Review
. 2013 Jun 14;19(22):3375-84.
doi: 10.3748/wjg.v19.i22.3375.

What about non-alcoholic fatty liver disease as a new criterion to define metabolic syndrome?

Giovanni Tarantino  1 , Carmine Finelli
Affiliations
Review

What about non-alcoholic fatty liver disease as a new criterion to define metabolic syndrome?

Giovanni Tarantino et al. World J Gastroenterol. .

Abstract

Non-alcoholic fatty liver disease (NAFLD) is currently not a component of the diagnostic criteria for metabolic syndrome (MetS); however, the development of NAFLD has some common mechanisms with the development of MetS, as they share the pathophysiologic basis of insulin resistance. It is also recognized that NAFLD is the hepatic manifestation of MetS. To define MetS, the presence of at least three of the proposed criteria is required, and sometimes it is sufficient to have only one laboratory value, modified by diet or drugs, for the classification of MetS. Ultrasonographically-detected NAFLD (US-NAFLD) is more stable, only changing during the middle- to long-term. Although controversies over MetS continue, and considering that abdominal ultrasonography for diagnosing NAFLD has high specificity and guidelines to modify the natural course of NAFLD by diet composition or lifestyle have not yet been established, why should we not introduce US-NAFLD as a new criterion to define MetS?

Keywords: Criteria; Metabolic syndrome; Non-alcoholic fatty liver disease; Nonalcoholic steatohepatitis; Ultrasonography.

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Figures

Figure 1
Figure 1
The lipid overflow-ectopic fat model. FFA: Free fatty acid.
See this image and copyright information in PMC

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