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. 2013 May 21;47(2):111-8.
doi: 10.2478/raon-2013-0027. Print 2013 Jun.

Poor outcome of comprehensive therapy in a case of laryngeal synovial sarcoma

Yang-Yang Bao  1 , Quin-Ying Wang, Shui-Hong Zhou, Kui Zhao, Ling-Xiang Ruan, Hong-Tian Yao
Affiliations

Poor outcome of comprehensive therapy in a case of laryngeal synovial sarcoma

Yang-Yang Bao et al. Radiol Oncol. .

Abstract

Background: Synovial sarcoma is common in the extremities. Our search revealed only 17 cases of synovial sarcoma of the larynx in the English-language literature.

Case report: We report an additional case of a 37-year-old man with primary laryngeal synovial sarcoma who underwent positron emission tomography/computed tomography (PET/CT) following the treatment. Although the patient received comprehensive therapy including surgery, radiotherapy, repeated chemotherapies, and targeted therapies, he had an unfavourable outcome and died of distant metastases.

Conclusions: In synovial sarcoma of the larynx, PET/CT can detect recurrence and metastasis. PET/CT can also predict the treatment effect in patients with synovial sarcoma.

Keywords: PET/CT; follow up; larynx; synovial sarcoma.

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Figures

FIGURE 1
FIGURE 1
(a) The mass was tan-red and irregular and had an ulcer covered by blood clots and a fleshy cut surface. (b) Surgical sample.
FIGURE 2
FIGURE 2
(a) Pathology showed that the tumour consisted of small, uniform spindle cells invading the surrounding muscles (HE×20). (b) Immunohistochemical examination for vimentin was positive (EliVision×20).
FIGURE 3
FIGURE 3
PET/CT showed high FDG uptake in the region of the right hypopharynx and laryngeal inlet (SUVmax = 4.1) and no distant metastasis.
FIGURE 4
FIGURE 4
(a, b) Nine months after the second surgery, PET/CT revealed high FDG uptake in the right submaxillary lymph node (SUVmax= 3.2), right oropharynx (SUVmax= 5.4) and(c) multiple nodules in both lungs (SUVmax= 4.6).
FIGURE 5
FIGURE 5
After radiotherapy, repeated chemotherapies and targeted therapies, (a) a whole body scan showed FDG uptake in the right neck and lung. (b) PET/CT revealed a 7.5 × 9-cm mass in the right submaxillary region with high FDG uptake (SUVmax = 5.2) involving the right parotid gland, right tongue base, right mandible, jugular vein, carotid artery, and surrounding muscles. (c) Multiple nodules in both lungs, were evident with the largest being up to 6.68 cm in diameter (SUVmax= 6.02).
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