Prevention versus intervention of type 1 diabetes
- PMID: 23803322
- DOI: 10.1016/j.clim.2013.05.018
Prevention versus intervention of type 1 diabetes
Abstract
Type 1 diabetes (T1D) is a cell-mediated autoimmune disease. New cases of T1D are on the increase and exogenous insulin therapy is the only intervention regularly initiated for T1D patients. Though tremendous strides have been made in prediction of T1D, prevention and intervention strategies have not experienced the same success. In this review, we will discuss some possible reasons why new intervention therapies for T1D have not been implemented into the mainstream treatment regimen for T1D patients. We will also discuss potential caveats for why prevention and intervention trials in T1D may not have experienced the same success as prediction trials.
Keywords: Intervention; Islet autoimmunity; Prediction; Prevention; Type 1 diabetes; Type 2 diabetes.
Copyright © 2013 Elsevier Inc. All rights reserved.
Similar articles
-
Lessons from type 1 diabetes for understanding natural history and prevention of autoimmune disease.Rheum Dis Clin North Am. 2014 Nov;40(4):797-811. doi: 10.1016/j.rdc.2014.07.008. Epub 2014 Sep 2. Rheum Dis Clin North Am. 2014. PMID: 25437293 Free PMC article. Review.
-
Immunotherapy trials for type 1 diabetes: the contribution of George Eisenbarth.Diabetes Technol Ther. 2013 Jun;15 Suppl 2(Suppl 2):S2-13-S2-20. doi: 10.1089/dia.2013.0107. Diabetes Technol Ther. 2013. PMID: 23786294 Free PMC article.
-
Trials in type 1 diabetes: Antigen-specific therapies.Clin Immunol. 2013 Dec;149(3):345-55. doi: 10.1016/j.clim.2013.02.002. Epub 2013 Feb 15. Clin Immunol. 2013. PMID: 23490422 Free PMC article. Review.
-
Making progress: preserving beta cells in type 1 diabetes.Ann N Y Acad Sci. 2011 Dec;1243:119-34. doi: 10.1111/j.1749-6632.2011.06321.x. Ann N Y Acad Sci. 2011. PMID: 22211897 Review.
-
Immunotherapies in diabetes mellitus type 1.Med Clin North Am. 2012 May;96(3):621-34, xi. doi: 10.1016/j.mcna.2012.04.008. Epub 2012 May 24. Med Clin North Am. 2012. PMID: 22703858 Review.
Cited by
-
Nano-curcumin safely prevents streptozotocin-induced inflammation and apoptosis in pancreatic beta cells for effective management of Type 1 diabetes mellitus.Br J Pharmacol. 2017 Jul;174(13):2074-2084. doi: 10.1111/bph.13816. Epub 2017 May 30. Br J Pharmacol. 2017. PMID: 28409821 Free PMC article.
-
Autoimmune diabetes recurrence should be routinely monitored after pancreas transplantation.World J Transplant. 2014 Sep 24;4(3):183-7. doi: 10.5500/wjt.v4.i3.183. World J Transplant. 2014. PMID: 25346891 Free PMC article. Review.
-
The role of the innate immune system in destruction of pancreatic beta cells in NOD mice and humans with type I diabetes.J Autoimmun. 2016 Jul;71:26-34. doi: 10.1016/j.jaut.2016.03.006. Epub 2016 Mar 24. J Autoimmun. 2016. PMID: 27021275 Free PMC article. Review.
-
Antigen-based immunotherapies do not prevent progression of recent-onset autoimmune diabetes: a systematic review and meta-analysis.Endocrine. 2016 Dec;54(3):620-633. doi: 10.1007/s12020-016-1033-3. Epub 2016 Jul 29. Endocrine. 2016. PMID: 27473096
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
