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Case Reports
. 1990 Jul;28(7):1616-22.
doi: 10.1128/jcm.28.7.1616-1622.1990.

Trichosporon beigelii, an emerging pathogen resistant to amphotericin B

T J Walsh  1 , G P Melcher, M G Rinaldi, J Lecciones, D A McGough, P Kelly, J Lee, D Callender, M Rubin, P A Pizzo
Affiliations
Case Reports

Trichosporon beigelii, an emerging pathogen resistant to amphotericin B

T J Walsh et al. J Clin Microbiol. 1990 Jul.

Abstract

Trichosporon beigelii caused fatal disseminated infections that were resistant to amphotericin B in two granulocytopenic patients. In vitro susceptibility studies demonstrated that both index strains of T. beigelii were inhibited but not killed by amphotericin B at achievable concentrations in serum. The minimum lethal concentration for both isolates was greater than or equal to 18 micrograms/ml. Five of seven other isolates were found to have a similar pattern of amphotericin B resistance. The fact that the minimum lethal concentration of T. beigelii was many times greater than its MIC was consistent with a resistance pattern of tolerance. We concluded that T. beigelii may be resistant in vitro to amphotericin B and that this in vitro resistance was correlated with refractory, disseminated trichosporonosis in granulocytopenic patients. T. beigelii should be included in the expanding list of amphotericin B-resistant fungi.

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