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Comparative Study
. 2013 Sep;51(9):3087-9.
doi: 10.1128/JCM.00798-13. Epub 2013 Jun 26.

Algorithm-based prediction of HIV-1 subtype D coreceptor use

Julia Dina  1 , Stephanie Raymond, Anne Maillard, Helene Le Guillou-Guillemette, Audrey Rodalec, Agnes Beby-Defaux, Genevieve Giraudeau, Sophie Vallet, Thomas Mourez, Christopher Payan, Astrid Vabret, Annick Ruffault, Virginie Ferre, Jacques Izopet, Jean-Christophe Plantier
Affiliations
Comparative Study

Algorithm-based prediction of HIV-1 subtype D coreceptor use

Julia Dina et al. J Clin Microbiol. 2013 Sep.

Abstract

We compared the coreceptor tropism-predicting performance of a specific genotypic algorithm for HIV-1 subtype D and that of the geno2pheno algorithm with different cutoffs. The D-specific algorithm and geno2pheno with a false-positivity rate cutoff of 2.5% had the same concordance with the phenotypic determination. The geno2pheno algorithm with a false-positivity rate cutoff of 2.5%, more sensitive but slightly less specific, seems to be an appropriate alternative.

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