Review
doi: 10.15690/vramn.v68i1.535.
[Kynurenines in pathogenesis of endogenous psychiatric disorders]
[Article in
Russian]
- PMID: 23805637
- DOI: 10.15690/vramn.v68i1.535
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Review
[Kynurenines in pathogenesis of endogenous psychiatric disorders]
[Article in
Russian]
Vestn Ross Akad Med Nauk.
2013.
Abstract
The essential amino acid tryptophan is metabolized on the methoxyindole pathway to serotonin, melatonin and 5-hydroxyindoleacetic acid and on the kynurenine pathway to kynurenine and related neuroactive metabolites, including 3-hydroxykynurenine, kynurenic acid, quinolinic acid and xanthurenic acid. Kynurenine and related metabolites play a significant role in the pathogenesis of major depressive disorder and schizophrenia. This paper is the review of literature data on the most modern state of this problem.
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