Histone deacetylases in herpesvirus replication and virus-stimulated host defense
- PMID: 23807710
- PMCID: PMC3738950
- DOI: 10.3390/v5071607
Histone deacetylases in herpesvirus replication and virus-stimulated host defense
Abstract
Emerging evidence highlights a critical role for protein acetylation during herpesvirus infection. As prominent modulators of protein acetylation, histone deacetylases (HDACs) are essential transcriptional and epigenetic regulators. Not surprisingly, viruses have evolved a wide array of mechanisms to subvert HDAC functions. Here, we review the mechanisms underlying HDAC regulation during herpesvirus infection. We next discuss the roles of acetylation in host defense against herpesvirus infection. Finally, we provide a perspective on the contribution of current mass spectrometry-based "omic" technologies to infectious disease research, offering a systems biology view of infection.
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References
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- Meier J.L. Reactivation of the human cytomegalovirus major immediate-early regulatory region and viral replication in embryonal NTera2 cells: Role of trichostatin a, retinoic acid, and deletion of the 21-base-pair repeats and modulator. J. Virol. 2001;75:1581–1593. doi: 10.1128/JVI.75.4.1581-1593.2001. - DOI - PMC - PubMed
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