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. 2013 Jul 8;69(27-28):5744-5750.
doi: 10.1016/j.tet.2013.04.071.

Cationic dirhodium carboxylate-catalyzed synthesis of dihydropyrimidones from propargyl ureas

Miao Yang  1 , Shannon J Odelberg, Zongzhong Tong, Dean Y Li, Ryan E Looper
Affiliations

Cationic dirhodium carboxylate-catalyzed synthesis of dihydropyrimidones from propargyl ureas

Miao Yang et al. Tetrahedron. .

Abstract

Cationic Rh(II) complexes are able to catalyze the regioselective hydroamination of propargyl ureas in a 6-endo fashion. This transformation permits access to interesting substitution patterns of dihydropyrimidines which have found use as nucleotide exchange factor inhibitors.

Keywords: ARF 6; Rhodium catalysis; dihydropyrimidone; heterocycle; hydroamination.

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Figures

Figure 1
Figure 1
Dihydropyrimidone strategy.
Figure 2
Figure 2
Manipulation of the secin scaffold for increased solubility.
See this image and copyright information in PMC

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