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. 2014 Jan;20(1):O27-9.
doi: 10.1111/1469-0691.12293. Epub 2013 Jun 28.

Emergence of VIM-4 metallo-β-lactamase-producing Klebsiella pneumoniae ST15 clone in the Clinical Centre University of Pécs, Hungary

S Melegh  1 , K Kovács, T Gám, A Nyul, B Patkó, A Tóth, I Damjanova, G Mestyán
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Free article

Emergence of VIM-4 metallo-β-lactamase-producing Klebsiella pneumoniae ST15 clone in the Clinical Centre University of Pécs, Hungary

S Melegh et al. Clin Microbiol Infect. 2014 Jan.
Free article

Abstract

Since November 2009 carbapenemase-producing Klebsiella pneumoniae isolates have been detected in increasing numbers at the Clinical Centre University of Pécs. Molecular typing was performed for 102 clinical isolates originating from different time periods and various departments of the Clinical Centre. Pulsed-field gel electrophoresis revealed the predominance of a single clone (101/102), identified as sequence type ST15. PCR and sequencing showed the presence of blaCTX-M-15 and blaVIM-4 genes. The blaVIM-4 was located on a class 1 integron designated In238b. To our knowledge, this is the first description of a blaVIM-4 gene in the predominant CTX-M-15 extended spectrum β-lactamase-producing Hungarian Epidemic Clone/ST15.

Keywords: Carbapenemase; In238b; Klebsiella pneumoniae; VIM-4; sequence type 15.

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