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Comment
. 2013 Jun 27;38(6):1085-8.
doi: 10.1016/j.immuni.2013.06.001.

K⁺ drops tilt the NLRP3 inflammasome

Thirumala-Devi Kanneganti  1 , Mohamed Lamkanfi
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K⁺ drops tilt the NLRP3 inflammasome

Thirumala-Devi Kanneganti et al. Immunity. .
Free article

Abstract

Unwarranted NLRP3 activation causes inflammatory disease. Its activation must therefore be specifically licensed. In this issue of Immunity, Munoz-Planillo et al. (2013) reveal K⁺ efflux as the sole common denominator of an array of unrelated stimuli engaging this inflammasome.

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