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. 2013 Sep;122(3):219-23.
doi: 10.1016/j.ijgo.2013.04.013. Epub 2013 Jun 28.

Pregnancy outcomes among women with Marfan syndrome

Sophie Omnes  1 , Guillaume Jondeau, Delphine Detaint, Agathe Dumont, Chadi Yazbeck, Jean Guglielminotti, Dominique Luton, Elie Azria
Affiliations

Pregnancy outcomes among women with Marfan syndrome

Sophie Omnes et al. Int J Gynaecol Obstet. 2013 Sep.

Abstract

Objective: To determine cardiac and obstetric outcomes among women with Marfan syndrome (MS) whose pregnancies were managed in accordance with the French national guidelines.

Methods: A descriptive analysis was conducted for a prospective cohort of 18 women with MS who gave birth in the maternity unit of Bichat-Claude Bernard Hospital, Paris, France, between January 1, 1998, and May 31, 2011. The study hospital was the national referral center for MS and related diseases.

Results: A total of 22 pregnancies were recorded among the study cohort. Of these, 21 were managed according to the national guidelines. One woman who was referred to the study hospital during late pregnancy was not managed according to the national guidelines; this patient experienced aortic dissection at 37 weeks. In the cohort, aortic diameter did not increase significantly during pregnancy. Vascular fetal growth restriction was observed in 7 (31.8 %) of the pregnancies. Cesarean delivery was planned for 17 (77.3%) of the pregnancies.

Conclusion: Risk of aortic dissection was low among a cohort of pregnant women with MS who were managed according to the French national guidelines.

Keywords: Aortic dissection; Fetal growth restriction; Marfan syndrome; National guidelines; Pregnancy; β-blocker.

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