Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Sep 30;213(3):230-4.
doi: 10.1016/j.pscychresns.2013.03.004. Epub 2013 Jun 27.

Magnetic resonance spectroscopy imaging of lactate in patients with bipolar disorder

Wen-Jang Chu  1 , Melissa P Delbello, Kelly B Jarvis, Mathew M Norris, Mi-Jung Kim, Wade Weber, Jing-Huei Lee, Stephen M Strakowski, Caleb M Adler
Affiliations

Magnetic resonance spectroscopy imaging of lactate in patients with bipolar disorder

Wen-Jang Chu et al. Psychiatry Res. .

Abstract

Although brain lactate levels are typically low and difficult to measure, a few previous investigators have reported that brain lactate levels are elevated in patients with bipolar disorder. The present study investigated the distribution of lactate in bipolar and healthy brains using 2D proton magnetic resonance spectroscopic imaging on a 4-Tesla magnetic resonance imaging system. Ratios of the concentration of lactate to N-acetylaspartate, and of lactate to total creatine, were significantly higher in bipolar than in healthy subjects. Lactate signals were primarily localized to the bipolar subjects' caudate and anterior cingulate cortices, components of the frontal-subcortical circuit, suggesting that affective dysregulation may be related to metabolic abnormalities in this network.

Keywords: Anterior cingulate cortex; Caudate; Magnetic resonance spectroscopy.

PubMed Disclaimer