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. 2014 Feb;69(2):174-81.
doi: 10.1093/gerona/glt088. Epub 2013 Jun 28.

Do changes in circulating biomarkers track with each other and with functional changes in older adults?

Jason L Sanders  1 , Victoria Ding, Alice M Arnold, Robert C Kaplan, Anne R Cappola, Jorge R Kizer, Robert M Boudreau, Mary Cushman, Anne B Newman
Affiliations

Do changes in circulating biomarkers track with each other and with functional changes in older adults?

Jason L Sanders et al. J Gerontol A Biol Sci Med Sci. 2014 Feb.

Abstract

Background: It is unclear if changes in proposed circulating biomarkers of aging are strongly correlated to each other or functional change. We tested if biomarker changes track with each other and with functional measures over 9 years in older adults.

Methods: Dehydroepiandrosterone sulfate (DHEAS), adiponectin, insulin-like growth factor 1 (IGF-1), IGF binding proteins 1 (IGFBP-1) and 3 (IGFBP-3), interleukin-6 (IL-6), cholesterol, and function (gait speed, grip strength, Modified Mini Mental Status Exam [3MSE] and Digit Symbol Substitution Test [DSST] scores) were measured in 1996-1997 and 2005-2006 in the Cardiovascular Health Study All Stars study (N = 901, mean [standard deviation, SD] age 85.3 [3.6] years in 2005-2006). Adjusted Pearson correlations illustrated if biomarkers tracked together. Multivariable linear regression demonstrated if biomarker changes tracked with functional changes.

Results: Correlations among biomarker changes were mostly <0.2. In models with each biomarker entered separately, a 1-SD increase biomarker change was associated with change in function as follows: grip strength (DHEAS β = 0.61kg, p = .001; IL-6 β = -0.46kg, p = .012; cholesterol men β = 0.79kg, p = .016); gait speed (DHEAS β = 0.02 meters per second, p = .039; IL-6 β = -0.018 meters per second, p = .049); and DSST score (DHEAS women β = 1.46, p = .004; IL-6 β = -0.83, p = .027). When biomarkers were entered in the same model, significant associations remaining were as follows: grip strength (DHEAS β = 0.54kg, p = .005; IL-6 β = -0.43kg, p = .022); 3MSE score (IGF-1 β = 0.96, p = .04; IGFBP-3 β = -1.07, p = .024); and DSST score (DHEAS women β = 1.27, p = .012; IL-6 β = -0.80, p = .04).

Conclusion: Changes in biomarkers were poorly correlated, supporting a model of stochastic, independent change across systems. DHEAS and IL-6 tracked most closely with function, illustrating that changes in inflammation and sex steroids may play dominant roles in changes of these functional outcomes.

Keywords: Biomarkers; Epidemiology; Functional performance; Inflammation; Longevity.

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References

    1. Baker GT, III, Sprott RL. Biomarkers of aging. Exp Gerontol. 1988;23:223–239 - PubMed
    1. Newman AB, Arnold AM, Sachs MC, et al. Long-term function in an older cohort–the cardiovascular health study all stars study. J Am Geriatr Soc. 2009;57(3):432–440 - PMC - PubMed
    1. Fried LP, Borhani NO, Enright P, et al. The Cardiovascular Health Study: design and rationale. Ann Epidemiol. 1991; 1(3):263–276 - PubMed
    1. Tell GS, Fried LP, Hermanson B, Manolio TA, Newman AB, Borhani NO. Recruitment of adults 65 years and older as participants in the Cardiovascular Health Study. Ann Epidemiol. 1993; 3(4):358–366 - PubMed
    1. Kaplan RC, McGinn AP, Pollak MN, et al. Total insulin like growth factor 1 and insulin like growth factor binding protein levels, functional status, and mortality in older adults. J Am Geriatr Soc. 2008; 56(4):652–660 - PubMed

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