Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Sep 5;23(5):351-9.
doi: 10.2188/jea.je20130004. Epub 2013 Jun 29.

Effect of age on the association between waist-to-height ratio and incidence of cardiovascular disease: the Suita study

Yukako Tatsumi  1 , Makoto Watanabe, Yoshihiro Kokubo, Kunihiro Nishimura, Aya Higashiyama, Tomonori Okamura, Akira Okayama, Yoshihiro Miyamoto
Affiliations

Effect of age on the association between waist-to-height ratio and incidence of cardiovascular disease: the Suita study

Yukako Tatsumi et al. J Epidemiol. .

Abstract
in English, Japanese

Background: Waist-to-height ratio (WHtR) has been shown to be a useful screening tool for metabolic syndrome and cardiovascular disease (CVD). We investigated the association of WHtR with CVD incidence by age group.

Methods: We conducted a 13.0-year cohort study of Japanese adults (2600 men and 2888 women) with no history of CVD. WHtR was calculated as waist circumference (cm) (WC) divided by height (cm). We stratified participants by sex and age group (30-49, 50-69, ≥70 years). Using the Cox proportional hazards model, we calculated hazard ratios (HRs) and 95% CIs for CVD in relation to WHtR quartile for participants aged 50 to 69 years and 70 years or older.

Results: Men aged 50 to 69 years in the highest quartile had significantly increased risks of CVD and coronary heart disease as compared with the lowest quartile; the HRs (95% CI) were 1.82 (1.13-2.92) and 2.42 (1.15-5.12), respectively. Women aged 50 to 69 years in the highest quartile had a significantly increased risk of stroke (HR, 2.43; 95% CI, 1.01-5.85). No significant results were observed in men or women aged 70 years or older. The likelihood ratio test showed that the predictive value of WHtR was greater than that of WC among men aged 50 to 69 years.

Conclusions: The association between WHtR and CVD risk differed among age groups. WHtR was useful in identifying middle-aged Japanese at higher risk of CVD and was a better predictor than WC of CVD, especially in men.

背景：: 腹囲だけでなく、腹囲・身長比も循環器疾患およびメタボリックシンドロームのスクリーニングに有用であることが報告されているが、年齢の影響を考慮した報告は限られている。そこで、本研究では腹囲・身長比と循環器疾患の発症の関連を年齢階級別に検討した。

方法：: 1989-1994年に大阪府吹田市住民から無作為抽出された循環器疾患（冠動脈疾患・脳卒中）の既往のない30-83歳の5488名（女性2888名、男性2600名）を平均13年間追跡した。性別・年齢階級別(50-69歳、70歳以上)に腹囲・身長比の四分位と循環器疾患発症との関連を、Cox比例ハザードモデルを用いて検討した。

結果：: 50-69歳男性において、総循環器疾患および冠動脈疾患で有意にリスクが上昇し、第4四分位のハザード比(95%信頼区間)は、第1四分位を基準として、それぞれ1.82（1.13-2.92）、2.42 (1.15-5.12)であった。女性では脳卒中で有意にリスクが上昇し、ハザード比は2.43 (1.01-5.85)であった。男女とも、70歳以上では有意なリスクの上昇は見られなかった。尤度比検定より、腹囲・身長比は50-69歳の男性において腹囲より高い予測力を示した。

結論：: 腹囲・身長比と循環器疾患発症の関係は年齢階級により異なっていた。腹囲・身長比は日本人の中年男女において循環器疾患発症のハイリスク者を特定するのに有用であり、特に中年男性においては、腹囲よりも予測力が高かった。

PubMed Disclaimer

Figures

Figure.
Figure.. (a) Average WC (waist circumference), height, and (b) waist-to-height ratio according to age (The Suita Study, Japan)
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Kaplan NM The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch Intern Med. 1989;149:1514–20 10.1001/archinte.1989.00390070054005 - DOI - PubMed
    1. DeFronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care. 1991;14:173–94 10.2337/diacare.14.3.173 - DOI - PubMed
    1. Han TS, van Leer EM, Seidell JC, Lean ME. Waist circumference action levels in the identification of cardiovascular risk factors: prevalence study in a random sample. BMJ. 1995;311:1401–5 10.1136/bmj.311.7017.1401 - DOI - PMC - PubMed
    1. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. ; International Diabetes Federation Task Force on Epidemiology and Prevention; Hational Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; International Association for the Study of Obesity . Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120:1640–5 10.1161/CIRCULATIONAHA.109.192644 - DOI - PubMed
    1. Pischon T, Boeing H, Hoffmann K, Bergmann M, Schulze MB, Overvad K, et al. . General and abdominal adiposity and risk of death in Europe. N Engl J Med. 2008;359:2105–20 10.1056/NEJMoa0801891 - DOI - PubMed

Publication types