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Comment
. 2013 Jul;21(7):1294-6.
doi: 10.1038/mt.2013.130.

Exosome-like nanoparticles from food: protective nanoshuttles for bioactive cargo

Michel Record  1
Affiliations
Comment

Exosome-like nanoparticles from food: protective nanoshuttles for bioactive cargo

Michel Record. Mol Ther. 2013 Jul.
No abstract available

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Figures

Figure 1
Figure 1
From grapes to exosome-like nanovesicles. Regular grapes contain nanovesicles that can be isolated after crushing by ultracentrifugation. When orally administrated to mice, grape exosome-like nanoparticles (GELNs) can pass through the digestive tract and trigger recovery of chemically induced colitis. GELNs enter intestinal stem cells by macropinocytosis and stimulate their proliferation both by activation of the Wnt/β-catenin/GSK3 pathway and by the mitogenic lipid phosphatidic acid, whose effect might involve the mammalian target of rapamycin (mTOR) complex. DSS, dextran sodium sulfate; LEF, lymphoid enhancer factor; TCF, T-cell factor.
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References

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