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Randomized Controlled Trial
. 2013 Oct;17(8):2816-29.
doi: 10.1007/s10461-013-0538-5.

A preliminary RCT of CBT-AD for adherence and depression among HIV-positive Latinos on the U.S.-Mexico border: the Nuevo Día study

Jane M Simoni  1 , John S Wiebe, John A Sauceda, David Huh, Giselle Sanchez, Virginia Longoria, C Andres Bedoya, Steven A Safren
Affiliations
Randomized Controlled Trial

A preliminary RCT of CBT-AD for adherence and depression among HIV-positive Latinos on the U.S.-Mexico border: the Nuevo Día study

Jane M Simoni et al. AIDS Behav. 2013 Oct.

Abstract

We conducted a preliminary RCT among 40 HIV-positive Latinos of Mexican descent on the U.S.-Mexico border who indicated imperfect adherence and depressive symptomatology. Participants were randomly assigned to culturally adapted cognitive-behavioral therapy for adherence and depression with an alarmed pillbox or usual care. Outcomes were depressive symptoms (self-report and blind clinician ratings), adherence (self-report and electronic pillbox), and biological markers. The intervention, delivered in English and Spanish, proved feasible and acceptable. Generalized estimating equations in intent-to-treat analyses showed some effects of "moderate" to "large" size, with maintenance over time. For example, intervention (vs. control) participants demonstrated at post-intervention a greater drop in BDI scores (OR = -3.64, p = 0.05) and greater adherence according to the electronic pillbox (OR = 3.78, p = 0.03). Biological markers indicated some relative improvement for CD4 count but not VL. The promising results suggest a larger trial to determine efficacy is warranted.

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Figures

Figure 1
Figure 1
Flow chart of participants.
Figure 2
Figure 2
Primary and secondary outcomes at 0, 6, and 9 months by study arm according to the longitudinal GEE models: a) Self-report and EDM adherence, b) BDI and MADRS depression, c) Viral load and CD4 count.
See this image and copyright information in PMC

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