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Meta-Analysis
. 2013 Aug;28(5):517-23.
doi: 10.1177/1533317513494450. Epub 2013 Jun 28.

Meta-analysis of the association between urokinase-plasminogen activator gene rs2227564 polymorphism and Alzheimer's disease

Wenlong Wu  1 , Hong Jiang, Meiyun Wang, Dongfeng Zhang
Affiliations
Meta-Analysis

Meta-analysis of the association between urokinase-plasminogen activator gene rs2227564 polymorphism and Alzheimer's disease

Wenlong Wu et al. Am J Alzheimers Dis Other Demen. 2013 Aug.

Abstract

Objective: The association between urokinase-plasminogen activator (PLAU) gene rs2227564 polymorphism and Alzheimer's disease (AD) risk has been widely reported across different ethnic populations, with inconsistent results. Thus, we performed a meta-analysis to assess the association between PLAU rs2227564 polymorphism and AD risk.

Methods: Fixed or random effect model was used as the pooling method to assess the basis of homogeneity test among studies. Summarized estimation of odds ratio (OR) and 95% confidence interval (CI) were calculated. Heterogeneity among studies was evaluated using Q test and I (2). Publication bias was estimated using Harbord's test.

Results: A total of 27 studies (comprising 6100 AD cases and 5718 controls) were included in this meta-analysis. The present meta-analysis showed a significant increased effect of T allele on risk of AD in dominant model (fixed effect model [FEM] OR 1.123, 95% CI 1.025-1.231) and heterozygote comparison (CT vs CC; FEM OR 1.126, 95% CI 1.027-1.235). No publication bias was detected.

Conclusion: This meta-analysis showed that T allele of rs2227564 polymorphism in PLAU gene could increase the effects on risk of AD, and this result needs to be confirmed by further studies.

Keywords: Alzheimer’s disease; meta-analysis; polymorphism; urokinase-plasminogen activator gene.

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Conflict of interest statement

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Forest plots of relationship between urokinase-plasminogen activator (PLAU) gene rs2227564 polymorphism and Alzheimer’s disease (AD) in dominant model (TT + CT vs CC) after excluding the studies that deviated from Hardy-Weinberg equilibrium (HWE) in cases and/or control groups and sensitivity analysis. White diamond denotes the pooled odds ratio (OR). Black squares indicate the OR in each study, with square sizes inversely proportional to the standard error of the OR. Horizontal lines represent 95% confidence interval (CI).
See this image and copyright information in PMC

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