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Editorial
. 2013 Jul;98(7):993-5.
doi: 10.3324/haematol.2013.084293.

Mitochondria underlie different metabolism of hematopoietic stem and progenitor cells

Lorena Arranz, Alvaro Urbano-Ispizúa, Simón Méndez-Ferrer
Editorial

Mitochondria underlie different metabolism of hematopoietic stem and progenitor cells

Lorena Arranz et al. Haematologica. 2013 Jul.
No abstract available

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Figures

Figure 1.
Figure 1.
ROS produced during mitochondrial metabolism determine the fate of HSC. Quiescent LT-HSC possess protective mechanisms to prevent abnormally high ROS levels, including low mitochondrial content, preferential use of glycolysis and reinforced antioxidant defenses. Small changes in ROS content may affect HSC fate, stimulating these cells’ proliferation and differentiation, and reducing their self-renewal capacity. High levels of ROS may lead to either HSC apoptosis or transformation.
See this image and copyright information in PMC

References

    1. Parmar K, Mauch P, Vergilio JA, Sackstein R, Down JD. Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc Natl Acad Sci USA. 2007;104(13):5431–6 - PMC - PubMed
    1. Simsek T, Kocabas F, Zheng J, Deberardinis RJ, Mahmoud AI, Olson EN, et al. The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell. 2010;7(3):380–90 - PMC - PubMed
    1. Mendez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, Macarthur BD, Lira SA, et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature. 2010;466(7308):829–34 - PMC - PubMed
    1. Mendez-Ferrer S, Lucas D, Battista M, Frenette PS. Haematopoietic stem cell release is regulated by circadian oscillations. Nature. 2008;452(7186):442–7 - PubMed
    1. Takubo K, Nagamatsu G, Kobayashi CI, Nakamura-Ishizu A, Kobayashi H, Ikeda E, et al. Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. Cell Stem Cell. 2013;12(1):49–61 - PMC - PubMed

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