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Case Reports
. 2013 Jun 25:2013:bcr2013009661.
doi: 10.1136/bcr-2013-009661.

Nebulised DNase post-therapeutic bronchoalveolar lavage in near fatal asthma exacerbation in an adult patient refractory to conventional treatment

A C L Chia  1 , D Menzies, D J McKeon
Affiliations
Case Reports

Nebulised DNase post-therapeutic bronchoalveolar lavage in near fatal asthma exacerbation in an adult patient refractory to conventional treatment

A C L Chia et al. BMJ Case Rep. .

Abstract

Mucus plugging plays a vital role in the pathophysiology of fatal and near fatal asthma as demonstrated in various postmortem studies. There is a paucity of published literature on how to manage mucus plugging in adult patients with refractory asthma exacerbation not responding to conventional therapies as compared with its paediatric cohort. We describe a dramatic improvement with the use of rhDNase, following bronchoalveolar lavage in an intubated adult female patient, with status asthmaticus refractory to conventional treatment.

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Figures

Figure 1
Figure 1
Coronal section of the lung showing sudden truncation of the bronchi.
See this image and copyright information in PMC

References

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