Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975;287(2):213-7.
doi: 10.1007/BF00510452.

Further evidence for a cAMP dependent regulation of tyrosine-3-monoxygenase induction in adrenal medulla: effect of denervation

I Hanbauer, A Guidotti

Further evidence for a cAMP dependent regulation of tyrosine-3-monoxygenase induction in adrenal medulla: effect of denervation

I Hanbauer et al. Naunyn Schmiedebergs Arch Pharmacol. 1975.

Abstract

Unilateral adrenal denervation caused a gradual decrease of adenylate cyclase activity in rat adrenal medulla. The extent of the increase in adrenal medullary 3',5'-cyclic adenosine monophosphate (cAMP) content elicited by injections of carbamylcholine declined gradually folling adrenal denervation. Three or nine days after denervation carbamylcholine caused rise of cAMP and a delayed increase of tyrosine-3-mono-oxygenase (TH) activity of similar magnitude in intact and denervated adrenal medullae. However, after an interval of 15 days or longer following denervation the increase in TH activity elicited by carbamylcholine was greatly reduced. These results support previous proposals that cAMP is involved as a second messenger in the trans-synaptic induction of TH.

PubMed Disclaimer

References

    1. Science. 1973 Mar 2;179(4076):902-4 - PubMed
    1. Mol Pharmacol. 1971 Jan;7(1):87-96 - PubMed
    1. Nature. 1961 Dec 16;192:1087-9 - PubMed
    1. Life Sci. 1974 Apr 1;14(7):1169-88 - PubMed
    1. J Pharmacol Exp Ther. 1969 Sep;169(1):74-9 - PubMed