Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 May;5(5):309-15.
doi: 10.4103/1947-2714.112473.

Hyaluronic Acid: a boon in periodontal therapy

Parveen Dahiya  1 , Reet Kamal
Affiliations

Hyaluronic Acid: a boon in periodontal therapy

Parveen Dahiya et al. N Am J Med Sci. 2013 May.

Abstract

Hyaluronic acid is a naturally occurring linear polysaccharide of the extracellular matrix of connective tissue, synovial fluid, and other tissues. Its use in the treatment of the inflammatory process is established in medical areas such as orthopedics, dermatology, and ophthalmology. The Pubmed/Medline database was searched for keywords "Hyaluronic acid and periodontal disease" and "Hyaluronic acid and gingivitis" which resulted in 89 and 22 articles respectively. Only highly relevant articles from electronic and manual search in English literature were selected for the present review article. In the field of dentistry, hyaluronic acid has shown anti-inflammatory and anti-bacterial effects in the treatment of periodontal diseases. Due to its tissue healing properties, it could be used as an adjunct to mechanical therapy in the treatment of periodontitis. Further studies are required to determine the clinical efficacy of hyaluronic acid in healing of periodontal lesion. The aim of the present review, article is to discuss the role of hyaluronic acid in periodontal therapy.

Keywords: Gingivitis and periodontitis; Hyaluronic acid; Periodontal healing.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Structure of Hyaluronan. (a) Chemical structure of Hyaluronan. (b) 3D model of the Hyaluronan structure. (c) Hyaluronan is abundant, long, unsulfated glycosaminoglycan (up to 25,000 sugars), synthesized in the extra-cellular matrix by an enzyme complex in the plasma membrane
Figure 2
Figure 2
Properties of hyaluronic acid
Figure 3
Figure 3
Role of hyaluronic acid in wound healing
See this image and copyright information in PMC

References

    1. Pagnacco A, Vangelisti R, Erra C, Poma A. Double-blind clinical trial versus placebo of a new sodium-hyaluronate-based gingival gel. Attual Ter In. 1997;15:1–7.
    1. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet. 2005;366:1809–20. - PubMed
    1. Sardi Jde C. Oxidative stress in diabetes and periodontitis. N Am J Med Sci. 2013;5:58–9. - PMC - PubMed
    1. Pendyala G, Thomas B, Joshi SR. Evaluation of total antioxidant capacity of saliva in type 2 diabetic patients with and without periodontal disease: A case-control study. N Am J Med Sci. 2013;5:51–7. - PMC - PubMed
    1. Moseley R, Waddington RJ, Embery G. Hyaluronan and its potential role in periodontal healing. Dent Update. 2002;29:144–8. - PubMed