doi: 10.1159/000122390.
On the presence of a MSH-release inhibiting system in the rat neurointermediate lobe
- PMID: 238163
- DOI: 10.1159/000122390
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On the presence of a MSH-release inhibiting system in the rat neurointermediate lobe
Neuroendocrinology.
1975.
Abstract
Rat neurointermediate lobes were superfused in vitro and showed a stable secretion rate of MSH after 30 min. MSH secretion from lobes of untreated rats was reversibly inhibited during superfusion with medium containing 45 mM K+. This inhibition could not be induced using lobes from median eminence lesioned or reserpinized rats. Superfusion with 45 mM K+ also induced release of dopamine from lobes preincubated with the labeled transmitter. It is concluded that the MSH-release inhibiting system present in the rat neurointermediate lobe may be identical to the dopaminergic arcuate-intermediate lobe system.
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