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• Rapid intranasal delivery of chloramphenicol acetyltransferase in the active form to different brain regions as a model for enzyme therapy in the CNS.

  Appu AP, Arun P, Krishnan JKS, Moffett JR, Namboodiri AMA. Appu AP, et al. J Neurosci Methods. 2016 Feb 1;259:129-134. doi: 10.1016/j.jneumeth.2015.11.027. Epub 2015 Dec 10. J Neurosci Methods. 2016. PMID: 26688469 Free PMC article.
• Intranasal Insulin: a Treatment Strategy for Addiction.

  Kashyap B, Hanson LR, Frey Ii WH. Kashyap B, et al. Neurotherapeutics. 2020 Jan;17(1):105-115. doi: 10.1007/s13311-019-00822-4. Neurotherapeutics. 2020. PMID: 31898283 Free PMC article. Review.
• Intranasal Administration of Insulin Reduces Chronic Behavioral Abnormality and Neuronal Apoptosis Induced by General Anesthesia in Neonatal Mice.

  Li H, Dai CL, Gu JH, Peng S, Li J, Yu Q, Iqbal K, Liu F, Gong CX. Li H, et al. Front Neurosci. 2019 Jul 11;13:706. doi: 10.3389/fnins.2019.00706. eCollection 2019. Front Neurosci. 2019. PMID: 31354415 Free PMC article.
• Intranasal insulin for the treatment of alcohol use disorder: design and methodology of an alcohol interaction randomized controlled trial.

  Haass-Koffler CL, Kashyap B, Gully BJ, Nambiar SS, Hornbacher R, Foster SL, Silberman Y, Swift RM, Hanson LR, Frey WH 2nd. Haass-Koffler CL, et al. Contemp Clin Trials Commun. 2025 Jun 10;46:101509. doi: 10.1016/j.conctc.2025.101509. eCollection 2025 Aug. Contemp Clin Trials Commun. 2025. PMID: 40584152 Free PMC article.
• Effect of administration method, animal weight and age on the intranasal delivery of drugs to the brain.

  Krishnan JKS, Arun P, Chembukave B, Appu AP, Vijayakumar N, Moffett JR, Puthillathu N, Namboodiri AMA. Krishnan JKS, et al. J Neurosci Methods. 2017 Jul 15;286:16-21. doi: 10.1016/j.jneumeth.2017.05.012. Epub 2017 May 10. J Neurosci Methods. 2017. PMID: 28499841 Free PMC article.