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Comment
. 2013 Jul;15(7):721-3.
doi: 10.1038/ncb2794.

A wake-up call for hibernating tumour cells

Sara M Weis, David A Cheresh
Comment

A wake-up call for hibernating tumour cells

Sara M Weis et al. Nat Cell Biol. 2013 Jul.

Abstract

Disseminated tumour cells (DTCs) can adopt a state of long-term dormancy. However, when and why they emerge from quiescence has remained unclear. Distinct microvascular niches are now shown to regulate this process. Mature blood vessels produce signals that sustain tumour cell quiescence, whereas sprouting microvasculature provides stimuli that reactivate DTCs, leading to metastatic relapse.

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Comment on

  • The perivascular niche regulates breast tumour dormancy.
    Ghajar CM, Peinado H, Mori H, Matei IR, Evason KJ, Brazier H, Almeida D, Koller A, Hajjar KA, Stainier DY, Chen EI, Lyden D, Bissell MJ. Ghajar CM, et al. Nat Cell Biol. 2013 Jul;15(7):807-17. doi: 10.1038/ncb2767. Epub 2013 Jun 2. Nat Cell Biol. 2013. PMID: 23728425 Free PMC article.

References

    1. Nat Rev Cancer. 2007 Nov;7(11):834-46 - PubMed
    1. Princess Takamatsu Symp. 1991;22:339-47 - PubMed
    1. Cancer Metastasis Rev. 2012 Dec;31(3-4):429-40 - PubMed
    1. Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12396-400 - PubMed
    1. Nat Rev Cancer. 2006 Jul;6(7):506-20 - PubMed

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