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. 2013 Sep;57(9):4578-80.
doi: 10.1128/AAC.00878-13. Epub 2013 Jul 1.

Evaluation of the Carba NP test for rapid detection of carbapenemase-producing Enterobacteriaceae and Pseudomonas aeruginosa

Nathalie Tijet  1 , David Boyd, Samir N Patel, Michael R Mulvey, Roberto G Melano
Affiliations

Evaluation of the Carba NP test for rapid detection of carbapenemase-producing Enterobacteriaceae and Pseudomonas aeruginosa

Nathalie Tijet et al. Antimicrob Agents Chemother. 2013 Sep.

Abstract

The Carba NP test was evaluated against a panel of 244 carbapenemase- and non-carbapenemase-producing Enterobacteriaceae and Pseudomonas aeruginosa isolates. We confirmed the 100% specificity and positive predictive value of the test, but the sensitivity and negative predictive value were 72.5% and 69.2%, respectively, and increased to 80% and 77.3%, respectively, using a more concentrated bacterial extract. False-negative results were associated with mucoid strains or linked to enzymes with low carbapenemase activity, particularly OXA-48-like, which has emerged globally in enterobacteria.

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References

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